|
Candidate genes for ARVD [37] |
| Components of the desmosome |
| Desmosomal cadherins (desmocollins; desmogleins)* |
| Desmoplakin* |
| Emerin |
| Plectin |
| Plakophilin* |
| Tyrosine kinases that phosphorylate desmosomal proteins |
|
|
| Components of the adherens junction |
| α-catenin |
| β-catenin |
| γ-catenin (junctional plakoglobin)* |
| N-cadherin |
|
|
| Constituents of the gap junction |
| Connexin 43 |
|
|
| Others |
| Cardiac ryanodine receptor* |
| Components of dystrophic-glycoprotein complex |
| Desmin |
| Laminin receptor-1 |
| Myotonic dystrophy protein kinase-1 |
| Transforming growth factor β3* |
|
*genes that have been definitively implicated in ARVD. Of the other genes listed above, many are currently under investigation for a potential etiological role in ARVD |
Jain et al. Journal of Cardiovascular Magnetic Resonance 2008 10:32 doi:10.1186/1532-429X-10-32 |